研究業績


Tomizawa, K., and Wei, F.-Y.,

Posttranscriptional modifications in mitochondrial tRNA and its implication in mitochondrial translation and disease.

J Biochem. mvaa098 (2020) [pubmed]

Kanno, A., Asahara, S. I., Furubayashi, A., Masuda, K., Yoshitomi, R., Suzuki, E., Takai, T., Kimura-Koyanagi, M., Matsuda T, Bartolome, A., Hirota, Y., Yokoi, N., Inaba, Y., Inoue, H., Matsumoto, M., Inoue, K., Abe, T., Wei, F.-Y., Tomizawa, K., Ogawa, W., Seino, S., Kasuga, M., and Kido, Y.

GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.

JCI Insight. vol. 5, no. 9, e128820 (2020) [pubmed]

Hirayama, M., Wei, F.-Y., Chujo, T., Oki, S., Yakita, M., Kobayashi, D., Araki, N., Takahashi, N., Yoshida, R., Nakayama, H., and Tomizawa, K.

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.

Cell Rep., vol. 31, no. 1, 107464 (2020) [pubmed]

Fakruddin, M., Wei, F.-Y., Suzuki, T., Asano, K., Kaieda, T., Omori, A., Izumi, R., Fujimura, A., Kaitsuka, T., Miyata, K., Araki, K., Oike, Y., Scorrano, L., Suzuki, T., and Tomizawa, K.

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell Rep., vol. 22, no. 2, 482 (2018) [pubmed]

Akaike, T., Ida, T., Wei, F.-Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S., Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M., and Motohashi, H. 
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. 
Nat. Commun., vol. 8, no. 1, 1177 (2017) [pubmed]

Fakruddin, M., Wei, F.-Y., Emura, S., Matsuda, S., Yasukawa, T., Kang, D., and Tomizawa, K.
Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. 
Nucleic Acids Res., vol. 45, no. 20, pp. 11954–11961 (2017) [pubmed]

Takahashi, N., Wei, F.-Y., Watanabe, S., Hirayama, M., Ohuchi, Y., Fujimura, A., Kaitsuka, T., Ishii, I., Sawa, T., Nakayama, H., Akaike, T., and Tomizawa, K. 
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.

Nucleic Acids Res., vol. 45, no. 1, pp. 435–445 (2017) [pubmed]

Wu, Y., Wei, F.-Y., Kawarada, L., Suzuki, T., Araki, K., Komohara, Y., Fujimura, A., Kaitsuka, T., Takeya, M., Oike, Y., Suzuki, T., and Tomizawa, K. 
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. 
PLoS Genet., vol. 12, no. 9, e1006355 (2016) [pubmed]

Wei, F.-Y., Zhou, B., Suzuki, T., Miyata, K., Ujihara, Y., Horiguchi, H., Takahashi, N., Xie, P., Michiue, H., Fujimura, A., Kaitsuka, T., Matsui, H., Koga, Y., Mohri, S., Suzuki, T., Oike, Y., and Tomizawa, K. 
Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans. 
Cell Metab., vol. 21, no. 3, pp. 428–442 (2015) [pubmed]

Zhou, B., Wei, F.-Y., Kanai, N., Fujimura, A., Kaitsuka, T., and Tomizawa, K. 
Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human. 
Hum. Mol. Genet., vol. 23, no. 17, pp. 4639–4650 (2014) [pubmed]

Xie, P., Wei, F.-Y., Hirata, S., Kaitsuka, T., Suzuki, T., Suzuki, T., and Tomizawa, K.
Quantitative PCR measurement of tRNA 2-Methylthio modification for assessing type 2 diabetes risk.
Clin. Chem., vol. 59, no. 11, pp. 1604–1612 (2013) [pubmed]

Ueda, Y.,  Wei, F.-Y., Hide, T.-I., Michiue, H., Takayama, K., Kaitsuka, T., Nakamura, H., Makino, K., Kuratsu, J.-I., Futaki, S., and Tomizawa, K. 
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus. 
Biomaterials, vol. 33, no. 35, pp. 9061–9069 (2012) [pubmed]

Wei, F.-Y., Suzuki, T., Watanabe, S., Kimura, S., Kaitsuka, T., Fujimura, A., Matsui, H., Atta, M., Michiue, H., Fontecave, M., Yamagata, K., Suzuki, T., and Tomizawa, K. 
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice.
J. Clin. Invest., vol. 121, no. 9, pp. 3598–3608 (2011) [pubmed]

Arragain, S., Handelman, S. K., Forouhar, F., Wei, F.-Y., Tomizawa, K., Hunt, J. F., Douki, T., Fontecave, M., Mulliez, E., and Atta, M. 
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. 
J. Biol. Chem., vol. 285, no. 37, pp. 28425–28433 (2010) [pubmed]

Wei, F.-Y., Nagashima, K., Ohshima, T., Saheki, Y., Lu, Y.-F., Matsushita, M., Yamada, Y., Mikoshiba, K., Seino, Y., Matsui, H., and Tomizawa, K. 
Cdk5-dependent regulation of glucose-stimulated insulin secretion. 
Nat. Med., vol. 11, no. 10, pp. 1104–1108 (2005) [pubmed]