研究業績


Ogawa, A., Nagiri, C., Shihoya, W., Inoue, A., Kawakami, K., Hiratsuka, S., Aoki, J., Ito, Y., Suzuki, T., Suzuki, T., Inoue, T., Nureki, O., Tanihara, H., Tomizawa, K., and Wei, F.-Y.

N6-methyladnenosine (m6A) is an endogenous A3 adenosine receptor ligand

Mol Cell. 81: 1-16. (2021) [pubmed]

Tomizawa, K., and Wei, F.-Y.

Posttranscriptional modifications in mitochondrial tRNA and its implication in mitochondrial translation and disease.

J Biochem. 168 (5): 435-444. (2020) [pubmed]

Kanno, A., Asahara, S. I., Furubayashi, A., Masuda, K., Yoshitomi, R., Suzuki, E., Takai, T., Kimura-Koyanagi, M., Matsuda T, Bartolome, A., Hirota, Y., Yokoi, N., Inaba, Y., Inoue, H., Matsumoto, M., Inoue, K., Abe, T., Wei, F.-Y., Tomizawa, K., Ogawa, W., Seino, S., Kasuga, M., and Kido, Y.

GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.

JCI Insight. vol. 5, no. 9, e128820 (2020) [pubmed]

Hirayama, M., Wei, F.-Y., Chujo, T., Oki, S., Yakita, M., Kobayashi, D., Araki, N., Takahashi, N., Yoshida, R., Nakayama, H., and Tomizawa, K.

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression.

Cell Rep., vol. 31, no. 1, 107464 (2020) [pubmed]

Fakruddin, M., Wei, F.-Y., Suzuki, T., Asano, K., Kaieda, T., Omori, A., Izumi, R., Fujimura, A., Kaitsuka, T., Miyata, K., Araki, K., Oike, Y., Scorrano, L., Suzuki, T., and Tomizawa, K.

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Cell Rep., vol. 22, no. 2, 482 (2018) [pubmed]

Akaike, T., Ida, T., Wei, F.-Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S., Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M., and Motohashi, H. 
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. 
Nat. Commun., vol. 8, no. 1, 1177 (2017) [pubmed]

Fakruddin, M., Wei, F.-Y., Emura, S., Matsuda, S., Yasukawa, T., Kang, D., and Tomizawa, K.
Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. 
Nucleic Acids Res., vol. 45, no. 20, pp. 11954–11961 (2017) [pubmed]

Takahashi, N., Wei, F.-Y., Watanabe, S., Hirayama, M., Ohuchi, Y., Fujimura, A., Kaitsuka, T., Ishii, I., Sawa, T., Nakayama, H., Akaike, T., and Tomizawa, K. 
Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.

Nucleic Acids Res., vol. 45, no. 1, pp. 435–445 (2017) [pubmed]

Wu, Y., Wei, F.-Y., Kawarada, L., Suzuki, T., Araki, K., Komohara, Y., Fujimura, A., Kaitsuka, T., Takeya, M., Oike, Y., Suzuki, T., and Tomizawa, K. 
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. 
PLoS Genet., vol. 12, no. 9, e1006355 (2016) [pubmed]

Wei, F.-Y., Zhou, B., Suzuki, T., Miyata, K., Ujihara, Y., Horiguchi, H., Takahashi, N., Xie, P., Michiue, H., Fujimura, A., Kaitsuka, T., Matsui, H., Koga, Y., Mohri, S., Suzuki, T., Oike, Y., and Tomizawa, K. 
Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans. 
Cell Metab., vol. 21, no. 3, pp. 428–442 (2015) [pubmed]

Zhou, B., Wei, F.-Y., Kanai, N., Fujimura, A., Kaitsuka, T., and Tomizawa, K. 
Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human. 
Hum. Mol. Genet., vol. 23, no. 17, pp. 4639–4650 (2014) [pubmed]

Xie, P., Wei, F.-Y., Hirata, S., Kaitsuka, T., Suzuki, T., Suzuki, T., and Tomizawa, K.
Quantitative PCR measurement of tRNA 2-Methylthio modification for assessing type 2 diabetes risk.
Clin. Chem., vol. 59, no. 11, pp. 1604–1612 (2013) [pubmed]

Ueda, Y.,  Wei, F.-Y., Hide, T.-I., Michiue, H., Takayama, K., Kaitsuka, T., Nakamura, H., Makino, K., Kuratsu, J.-I., Futaki, S., and Tomizawa, K. 
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus. 
Biomaterials, vol. 33, no. 35, pp. 9061–9069 (2012) [pubmed]

Wei, F.-Y., Suzuki, T., Watanabe, S., Kimura, S., Kaitsuka, T., Fujimura, A., Matsui, H., Atta, M., Michiue, H., Fontecave, M., Yamagata, K., Suzuki, T., and Tomizawa, K. 
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice.
J. Clin. Invest., vol. 121, no. 9, pp. 3598–3608 (2011) [pubmed]

Arragain, S., Handelman, S. K., Forouhar, F., Wei, F.-Y., Tomizawa, K., Hunt, J. F., Douki, T., Fontecave, M., Mulliez, E., and Atta, M. 
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. 
J. Biol. Chem., vol. 285, no. 37, pp. 28425–28433 (2010) [pubmed]

Wei, F.-Y., Nagashima, K., Ohshima, T., Saheki, Y., Lu, Y.-F., Matsushita, M., Yamada, Y., Mikoshiba, K., Seino, Y., Matsui, H., and Tomizawa, K. 
Cdk5-dependent regulation of glucose-stimulated insulin secretion. 
Nat. Med., vol. 11, no. 10, pp. 1104–1108 (2005) [pubmed]